BDBM50299081 (S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)phenyl)benzofuran::CHEMBL574588

SMILES Cc1ccc(o1)-c1ccc2occ(-c3ccc(cc3)[S@](C)=O)c2c1

InChI Key InChIKey=WAODYHWCESZZOF-DEOSSOPVSA-N

Data  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50299081   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged CHK1 by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Src by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal 6xHis-tagged CDK1 by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal 6xHis-tagged CDK2 by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK5 by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged p38alpha by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged JNK1 by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged MEKK1 by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Lck by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged VEGFR2 by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged IKK-beta by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged CK1delta by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal peptide-tagged EGFR cytoplasmic domain by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal peptide-tagged ERBB2 cytoplasmic domain by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR3 by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDGFRalpha by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDGFRbeta by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TIE2 by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-Met by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-Kit by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of insulin receptor by [gamma-33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed