BDBM50303728 2-amino-4-(3-chlorophenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL578410

SMILES CN1C(N)=NC(C1=O)(c1ccccc1)c1cccc(Cl)c1

InChI Key InChIKey=QWEOCJPATDOXQJ-UHFFFAOYSA-N

Data  1 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50303728   

TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50303728(2-amino-4-(3-chlorophenyl)-1-methyl-4-phenyl-1H-im...)
Affinity DataKi:  300nMAssay Description:Inhibition of human BACE1 using QSY7EISEVNLDAEFC-Eu-amide as substrate incubated for 30 mins prior to substrate addition measured after 90 mins by FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50303728(2-amino-4-(3-chlorophenyl)-1-methyl-4-phenyl-1H-im...)
Affinity DataEC50:  6.97E+3nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303728(2-amino-4-(3-chlorophenyl)-1-methyl-4-phenyl-1H-im...)
Affinity DataIC50:  6.92E+4nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303728(2-amino-4-(3-chlorophenyl)-1-methyl-4-phenyl-1H-im...)
Affinity DataIC50:  420nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50303728(2-amino-4-(3-chlorophenyl)-1-methyl-4-phenyl-1H-im...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50303728(2-amino-4-(3-chlorophenyl)-1-methyl-4-phenyl-1H-im...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed