BDBM50303912 2,2'-methylenebis(4-chlorophenol)::3,3'-dichloro-6,6'-dihydroxydiphenylmethane::4-chloro-2-(5-chloro-2-hydroxybenzyl)phenol::CHEMBL33845::Dichlorophen::Dichlorophene

SMILES Oc1ccc(Cl)cc1Cc1cc(Cl)ccc1O

InChI Key InChIKey=MDNWOSOZYLHTCG-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50303912   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50303912(2,2'-methylenebis(4-chlorophenol) | 3,3'-dichloro-...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of human recombinant IDO expressed in Escherichia coli BL21 AIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50303912(2,2'-methylenebis(4-chlorophenol) | 3,3'-dichloro-...)
Affinity DataIC50:  8.41E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndoplasmic reticulum chaperone BiP(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50303912(2,2'-methylenebis(4-chlorophenol) | 3,3'-dichloro-...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of GRP78 (26 to 636 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 cells pre-incubated for 10 mins before FITC-NRLLLTG ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChaperonin GroEL(Escherichia coli)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50303912(2,2'-methylenebis(4-chlorophenol) | 3,3'-dichloro-...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50303912(2,2'-methylenebis(4-chlorophenol) | 3,3'-dichloro-...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50303912(2,2'-methylenebis(4-chlorophenol) | 3,3'-dichloro-...)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target60 kDa heat shock protein, mitochondrial(Homo sapiens)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50303912(2,2'-methylenebis(4-chlorophenol) | 3,3'-dichloro-...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThiosulfate sulfurtransferase(Homo sapiens)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50303912(2,2'-methylenebis(4-chlorophenol) | 3,3'-dichloro-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed