BDBM50304202 CHEMBL604483::N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyphenyl]-6'-methoxy-7'-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4'-amine

SMILES COc1cc2c(Oc3ccc(cc3F)-c3nc4ccccc4s3)ncnc2cc1OCCCN1CCN(C)CC1

InChI Key InChIKey=RGGYJEYZTPRESN-UHFFFAOYSA-N

Data  7 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50304202   

TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(CHEMBL604483 | N-Methyl-N-[4-(benzo[d]thiazol-2''-...)
Affinity DataEC50:  780nMAssay Description:Inhibition of VEGFR3 in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(CHEMBL604483 | N-Methyl-N-[4-(benzo[d]thiazol-2''-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of wild type EGF-R by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(CHEMBL604483 | N-Methyl-N-[4-(benzo[d]thiazol-2''-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of VEGFR3 by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(CHEMBL604483 | N-Methyl-N-[4-(benzo[d]thiazol-2''-...)
Affinity DataEC50:  300nMAssay Description:Inhibition of TIE2 in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(CHEMBL604483 | N-Methyl-N-[4-(benzo[d]thiazol-2''-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Aurora-B in human HCT116 cells by cellular proliferation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(CHEMBL604483 | N-Methyl-N-[4-(benzo[d]thiazol-2''-...)
Affinity DataIC50:  220nMAssay Description:Inhibition of Aurora-A by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(CHEMBL604483 | N-Methyl-N-[4-(benzo[d]thiazol-2''-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of EGFR in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(CHEMBL604483 | N-Methyl-N-[4-(benzo[d]thiazol-2''-...)
Affinity DataIC50:  420nMAssay Description:Inhibition of VEGFR2 by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(CHEMBL604483 | N-Methyl-N-[4-(benzo[d]thiazol-2''-...)
Affinity DataIC50:  88nMAssay Description:Inhibition of TIE2 by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(CHEMBL604483 | N-Methyl-N-[4-(benzo[d]thiazol-2''-...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of PDGFRbeta by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(CHEMBL604483 | N-Methyl-N-[4-(benzo[d]thiazol-2''-...)
Affinity DataIC50:  130nMAssay Description:Inhibition of Aurora-B by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed