BDBM50307129 3-((4-(dimethylamino)naphthalen-1-yl)methylene)-4-methylindolin-2-one::CHEMBL597960

SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3cccc(C)c23)c2ccccc12

InChI Key InChIKey=ZGNHCIFASHEGAU-AQTBWJFISA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50307129   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307129(3-((4-(dimethylamino)naphthalen-1-yl)methylene)-4-...)
Affinity DataIC50:  400nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307129(3-((4-(dimethylamino)naphthalen-1-yl)methylene)-4-...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307129(3-((4-(dimethylamino)naphthalen-1-yl)methylene)-4-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ALK by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307129(3-((4-(dimethylamino)naphthalen-1-yl)methylene)-4-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ABL by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed