BDBM50307140 (Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-pyridin-3-yl-1,3-dihydro-indol-2-one::CHEMBL602074

SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(cc23)-c2cccnc2)[nH]1

InChI Key InChIKey=BHEHWPCMASWZFW-YVLHZVERSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50307140   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307140((Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-pyr...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307140((Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-pyr...)
Affinity DataIC50:  580nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307140((Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-pyr...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of ALK by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307140((Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-pyr...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of ABL by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed