BDBM50307775 7-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide::CHEMBL598377

SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCCCCC(=O)NO

InChI Key InChIKey=RQYVKBOWLRVISJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50307775   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Curis

Curated by ChEMBL
LigandPNGBDBM50307775(7-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquina...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Curis

Curated by ChEMBL
LigandPNGBDBM50307775(7-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquina...)
Affinity DataIC50:  19nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Curis

Curated by ChEMBL
LigandPNGBDBM50307775(7-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquina...)
Affinity DataIC50:  19nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Curis

Curated by ChEMBL
LigandPNGBDBM50307775(7-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquina...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase(Homo sapiens (Human))
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50307775(7-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquina...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed