BDBM50307878 1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-oxo-2,3-dihydro-1Himidazo[4,5-b]pyridin-7-yloxy)phenyl)urea::CHEMBL597592

SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cccc4[nH]c(=O)[nH]c34)c2)n(n1)-c1ccccc1

InChI Key InChIKey=YLQMVIRZBOJBCV-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50307878   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  196nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  584nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of COTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  3.14E+3nMAssay Description:Inhibition of wild type BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  152nMAssay Description:Inhibition of p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  198nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  698nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  1.81E+3nMAssay Description:Inhibition of p38gamma MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed