BDBM50308204 2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one::CHEMBL598837

SMILES CCOc1ccc(Nc2ncc3CC(=O)Nc4cccnc4-c3n2)cc1

InChI Key InChIKey=LXRFOXKXUGKQGV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50308204   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308204(2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]py...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308204(2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]py...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308204(2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]py...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed