BDBM50309966 (exo)-N-(2-(2-hydroxy-2-phenylethyl)octahydrocyclopenta[c]pyrrol-5-yl)-1-methyl-N-(3-(trifluoromethoxy)benzyl)-1H-imidazole-4-carboxamide::CHEMBL597033

SMILES Cn1cnc(c1)C(=O)N(Cc1cccc(OC(F)(F)F)c1)[C@H]1C[C@H]2CN(CC(O)c3ccccc3)C[C@H]2C1

InChI Key InChIKey=KYCWFOMNQICMSP-XQLXZJNDSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50309966   

TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309966((exo)-N-(2-(2-hydroxy-2-phenylethyl)octahydrocyclo...)
Affinity DataKi:  2.80nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309966((exo)-N-(2-(2-hydroxy-2-phenylethyl)octahydrocyclo...)
Affinity DataKi:  177nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309966((exo)-N-(2-(2-hydroxy-2-phenylethyl)octahydrocyclo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309966((exo)-N-(2-(2-hydroxy-2-phenylethyl)octahydrocyclo...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309966((exo)-N-(2-(2-hydroxy-2-phenylethyl)octahydrocyclo...)
Affinity DataIC50:  3.88E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed