BDBM50312221 CHEMBL1079410::N-Benzyloxycarbonylamino-L-alanine-2S-pyrrolidine-2-carbonitrile

SMILES C[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C#N

InChI Key InChIKey=AHUJWMNUJZYLEX-JSGCOSHPSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50312221   

TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(CHEMBL1079410 | N-Benzyloxycarbonylamino-L-alanine...)
Affinity DataIC50:  3nMAssay Description:Inhibition of prolyl oligopeptidase in human LN229 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(CHEMBL1079410 | N-Benzyloxycarbonylamino-L-alanine...)
Affinity DataIC50:  5nMAssay Description:Inhibition of prolyl oligopeptidase in human LNZ308 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(CHEMBL1079410 | N-Benzyloxycarbonylamino-L-alanine...)
Affinity DataIC50:  29nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LNZ308 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(CHEMBL1079410 | N-Benzyloxycarbonylamino-L-alanine...)
Affinity DataIC50:  20nMAssay Description:Inhibition of prolyl oligopeptidase in intact human HCEC cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(CHEMBL1079410 | N-Benzyloxycarbonylamino-L-alanine...)
Affinity DataIC50:  28nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LN229 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(CHEMBL1079410 | N-Benzyloxycarbonylamino-L-alanine...)
Affinity DataIC50:  7nMAssay Description:Inhibition of prolyl oligopeptidase in human HCEC cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed