BDBM50313151 (S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop-1-enyl)-4,5-dihydro-1H-benzo[e][1,4]diazepin-3(2H)-one::CHEMBL1086744

SMILES [#6]-[#6](-[#6])-[#6]-[#6]-[#7]-1-[#6]-c2cc(\[#6]=[#6](/[#6])-[#6])c(-[#7])cc2-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6]-1=O

InChI Key InChIKey=VELGTNXAZBFHRD-NRFANRHFSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50313151   

TargetVitamin D3 receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313151((S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop...)
Affinity DataIC50:  2.00E+4nMAssay Description:Displacement of 1,25-dihydroxyvitamin D3 from GST-tagged VDR ligand binding domain assessed as inhibition of interaction with coactivator proteins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313151((S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop...)
Affinity DataIC50:  1.70E+4nMAssay Description:Antagonist activity at human recombinant VDR LBD expressed in HEK293 cells assessed as inhibition of 3 nM 1,25-(OH)2D3-induced transcriptional activa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313151((S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human recombinant GAL4N-fused VDR LBD expressed in HEK293 cells using 1,25(OH)2D3 as substrate assessed as inhibition of cofactor inter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313151((S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop...)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at human recombinant ERalpha LBD expressed in HEK293 cells assessed as inhibition of 0.3 nM estradiol-induced transcriptional act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313151((S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop...)
Affinity DataIC50:  2.20E+4nMAssay Description:Antagonist activity at human recombinant ERbeta LBD expressed in HEK293 cells assessed as inhibition of 0.3 nM estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313151((S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop...)
Affinity DataIC50:  2.30E+4nMAssay Description:Antagonist activity at human recombinant VDR LBD expressed in HEK293 cells assessed as inhibition of 300 nM 1,25-(OH)2D3-induced transcriptional acti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed