BDBM50315907 5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine::CHEMBL1091978

SMILES Cc1c(CN2CCN(CC2)S(C)(=O)=O)sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1

InChI Key InChIKey=AKKCGLXULFRAET-UHFFFAOYSA-N

Data  2 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50315907   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)
Affinity DataKi:  21nMAssay Description:Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)
Affinity DataKi:  21nMAssay Description:Inhibition of human recombinant mTOR expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 measured after 30 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kalpha assessed as reduction in 3,4,5-inositoltriphosphate accumulation after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PI3Kgamma using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3K subunit p110alpha assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)
Affinity DataIC50:  86nMAssay Description:Inhibition of PI3Kbeta using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3Kdelta using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)
Affinity DataIC50:  86nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed