BDBM50317580 4-(6-(2,4-difluorophenyl)-2-oxo-2H-quinolizin-1-yl)-3,5-difluorobenzonitrile::CHEMBL1098525

SMILES Fc1ccc(c(F)c1)-c1cccc2c(-c3c(F)cc(cc3F)C#N)c(=O)ccn12

InChI Key InChIKey=ADVMYQPPDMNMIL-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50317580   

TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317580(4-(6-(2,4-difluorophenyl)-2-oxo-2H-quinolizin-1-yl...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317580(4-(6-(2,4-difluorophenyl)-2-oxo-2H-quinolizin-1-yl...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed