BDBM50320213 CHEMBL1083022::isobutyl4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-methoxyphenylcarbamate

SMILES COc1cc(ccc1NC(=O)OCC(C)C)-c1cnc2c(cnn2c1N)-c1cccc(c1)N1CCN(C)CC1

InChI Key InChIKey=RZZRUWWETOHEPU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50320213   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Novartis Institute Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320213(CHEMBL1083022 | isobutyl4-(7-amino-3-(3-(4-methylp...)
Affinity DataIC50:  546nMAssay Description:Inhibition of LCK in human Jurkat cells assessed as ZAP70 phosphorylation by FACS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institute Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320213(CHEMBL1083022 | isobutyl4-(7-amino-3-(3-(4-methylp...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Novartis Institute Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320213(CHEMBL1083022 | isobutyl4-(7-amino-3-(3-(4-methylp...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Institute Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320213(CHEMBL1083022 | isobutyl4-(7-amino-3-(3-(4-methylp...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed