BDBM50321027 CHEMBL4175603
SMILES CCCC[C@@H]1CCCN1C(=O)c1cccc(c1)-c1cccc(c1)-n1ncc(C(O)=O)c1C1CC1
InChI Key InChIKey=BVWKAUMFAYUKCN-HSZRJFAPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50321027
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human Keap1 kelch domain (321 to 609 residues) binding to TAMRA-labeled Nrf2-ETGE peptide after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataEC50: 79nMAssay Description:Inhibition of Keap1/NRF2 interaction in human BEAS-2B cells assessed as upregulation of NQ01 after 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of full length Flag/His-tagged Keap1 kelch domain (unknown origin)/full length Avi-tagged Nrf2 (unknown origin) interaction after 2.25 hrs...More data for this Ligand-Target Pair