BDBM50324401 (E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)-benzoic Acid::CHEMBL1215292

SMILES COc1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1

InChI Key InChIKey=GNLVJIICVWDSNI-LFYBBSHMSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50324401   

TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50324401((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Affinity DataIC50: >3.00E+5nMAssay Description:Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(RAT)
Emory University

Curated by ChEMBL
LigandPNGBDBM50324401((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Affinity DataIC50:  6.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50324401((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Affinity DataIC50: >3.00E+5nMAssay Description:Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50324401((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Affinity DataIC50:  7.10E+3nMAssay Description:Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50324401((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Affinity DataIC50:  3.90E+3nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida glabrata)
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50324401((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Affinity DataIC50:  1.82E+5nMAssay Description:Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50324401((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Affinity DataIC50:  1.93E+5nMAssay Description:Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50324401((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Affinity DataIC50:  2.29E+5nMAssay Description:Antagonist activity at rat recombinant NR1-NR2A receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed