BDBM50324476 Benzylsulfonyl-D-arginyl-proline-(2-aminomethyl-5-chlorobenzyl)-amide Bis(trifluoroacetate)::CHEMBL1215084

SMILES NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NS(=O)(=O)Cc1ccccc1

InChI Key InChIKey=MWLLGEVAEDIFRC-PKTZIBPZSA-N

Data  5 KI

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50324476   

TargetProthrombin(Homo sapiens (Human))
Philipps-Universit£T Marburg

Curated by ChEMBL
LigandPNGBDBM50324476(Benzylsulfonyl-D-arginyl-proline-(2-aminomethyl-5-...)
Affinity DataKi:  0.290nMAssay Description:Inhibition of thrombin (unknown origin) using Tos-Gly-Pro-Arg-AMCA-TFA as a substrate incubated for 40 secs and measured every 15 secs interval for 2...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Philipps-Universit£T Marburg

Curated by ChEMBL
LigandPNGBDBM50324476(Benzylsulfonyl-D-arginyl-proline-(2-aminomethyl-5-...)
Affinity DataKi:  1nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50324476(Benzylsulfonyl-D-arginyl-proline-(2-aminomethyl-5-...)
Affinity DataKi:  220nMAssay Description:Inhibition of human recombinant matriptase catalytic domain expressed in HEK293 cells after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane protease serine 6(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50324476(Benzylsulfonyl-D-arginyl-proline-(2-aminomethyl-5-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human purified matriptase 2 catalytic domain expressed in HEK293 cells after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane protease serine 6(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50324476(Benzylsulfonyl-D-arginyl-proline-(2-aminomethyl-5-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant matriptase 2 expressed in HEK293 cells in conditioned medium after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed