BDBM50327658 11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl Ester::CHEMBL1085102::methyl 11H-dibenzo[b,e]azepine-10-carboxylate

SMILES COC(=O)c1cccc2C=Nc3ccccc3Cc12

InChI Key InChIKey=RNCCOSMXJQOWRS-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50327658   

TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -30 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  9.80nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at 75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  0.100nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  4.40nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as time point of maximal current amplitude by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -30 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  72nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed