BDBM50328085 6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)phenoxy)-1H-pyrazolo[3,4-b]pyridine::CHEMBL1257653

SMILES Cn1ncc2c(Oc3ccc(cc3)S(C)(=O)=O)cc(nc12)-c1cccc2[nH]ncc12

InChI Key InChIKey=DSBJBOOMYLWTSO-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50328085   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of DNA-PKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  7nMAssay Description:Inhibition of PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  187nMAssay Description:Inhibition of PI3Kalpha in human PC3 cells assessed as phosphorylated Akt levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  31nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed