BDBM50328927 (4-cyclopropylpiperazin-1-yl)(4-(3,4-dichlorophenoxy)-3-((methylamino)methyl)phenyl)methanone::CHEMBL402644

SMILES CNCc1cc(ccc1Oc1ccc(Cl)c(Cl)c1)C(=O)N1CCN(CC1)C1CC1

InChI Key InChIKey=SBAQYPMYNRQKBF-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50328927   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50328927((4-cyclopropylpiperazin-1-yl)(4-(3,4-dichloropheno...)
Affinity DataKi:  6.80nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50328927((4-cyclopropylpiperazin-1-yl)(4-(3,4-dichloropheno...)
Affinity DataKi:  9.30nMAssay Description:Inhibition of rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50328927((4-cyclopropylpiperazin-1-yl)(4-(3,4-dichloropheno...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by fluid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50328927((4-cyclopropylpiperazin-1-yl)(4-(3,4-dichloropheno...)
Affinity DataKi:  23nMAssay Description:Inhibition of human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50328927((4-cyclopropylpiperazin-1-yl)(4-(3,4-dichloropheno...)
Affinity DataKi:  490nMAssay Description:Binding affinity to human DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50328927((4-cyclopropylpiperazin-1-yl)(4-(3,4-dichloropheno...)
Affinity DataKi:  3.20E+3nMAssay Description:Binding affinity to human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed