BDBM50332592 CHEMBL1630791::D3RKN_90::cis-2-Hydroxy-1-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)ethanone

SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CO

InChI Key InChIKey=CCOHWQFOFWCBMH-PWSUYJOCSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50332592   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332592(CHEMBL1630791 | D3RKN_90 | cis-2-Hydroxy-1-(4-meth...)
Affinity DataIC50:  840nMAssay Description:Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332592(CHEMBL1630791 | D3RKN_90 | cis-2-Hydroxy-1-(4-meth...)
Affinity DataIC50:  480nMAssay Description:Inhibition of GST-tagged human JAK2 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50332592(CHEMBL1630791 | D3RKN_90 | cis-2-Hydroxy-1-(4-meth...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2023More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50332592(CHEMBL1630791 | D3RKN_90 | cis-2-Hydroxy-1-(4-meth...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2021More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332592(CHEMBL1630791 | D3RKN_90 | cis-2-Hydroxy-1-(4-meth...)
Affinity DataIC50:  32nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed