BDBM50332967 8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one::CHEMBL1629863

SMILES Clc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-c1ccncc1

InChI Key InChIKey=QWFYXUVFCJKYON-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50332967   

TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332967(8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332967(8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332967(8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,...)
Affinity DataIC50:  8nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed