BDBM50337128 2-((4-(4-hydroxypiperidin-1-yl)-2-methoxyphenyl)amino-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one::CHEMBL1673040::US9266890, IV-7

SMILES COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)N1CCC(O)CC1

InChI Key InChIKey=YSFFGUHMDPYPAW-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50337128   

TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50337128(2-((4-(4-hydroxypiperidin-1-yl)-2-methoxyphenyl)am...)
Affinity DataKd:  57nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337128(2-((4-(4-hydroxypiperidin-1-yl)-2-methoxyphenyl)am...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase DCLK1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337128(2-((4-(4-hydroxypiperidin-1-yl)-2-methoxyphenyl)am...)
Affinity DataIC50:  97nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DCLK1 (G351 to H689 residues) expressed in Escherichia coli BL21 DE3 using 5-FAM-KKLRRTLSVA-CO...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50337128(2-((4-(4-hydroxypiperidin-1-yl)-2-methoxyphenyl)am...)
Affinity DataIC50:  240nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed