BDBM50339998 (R)-2-(3-amino-1-phenylpropylthio)-4-chlorobenzonitrile fumarate::CHEMBL1762474

SMILES NCC[C@@H](Sc1cc(Cl)ccc1C#N)c1ccccc1

InChI Key InChIKey=OLZXHHOEVBLJLQ-OAHLLOKOSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50339998   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50339998((R)-2-(3-amino-1-phenylpropylthio)-4-chlorobenzoni...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50339998((R)-2-(3-amino-1-phenylpropylthio)-4-chlorobenzoni...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50339998((R)-2-(3-amino-1-phenylpropylthio)-4-chlorobenzoni...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50339998((R)-2-(3-amino-1-phenylpropylthio)-4-chlorobenzoni...)
Affinity DataIC50:  200nMAssay Description:Inhibition of iNOS in intact human DLD1 cells assessed as nitric oxide productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50339998((R)-2-(3-amino-1-phenylpropylthio)-4-chlorobenzoni...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed