BDBM50340004 (R)-2-(3-amino-1-(isoxazol-5-yl)propoxy)-6-(trifluoromethyl)nicotinonitrile oxalate::CHEMBL1762481

SMILES NCC[C@@H](Oc1nc(ccc1C#N)C(F)(F)F)c1ccno1

InChI Key InChIKey=SDRHZGGFUFCFFW-SECBINFHSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50340004   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340004((R)-2-(3-amino-1-(isoxazol-5-yl)propoxy)-6-(triflu...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340004((R)-2-(3-amino-1-(isoxazol-5-yl)propoxy)-6-(triflu...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340004((R)-2-(3-amino-1-(isoxazol-5-yl)propoxy)-6-(triflu...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human recombinant iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340004((R)-2-(3-amino-1-(isoxazol-5-yl)propoxy)-6-(triflu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340004((R)-2-(3-amino-1-(isoxazol-5-yl)propoxy)-6-(triflu...)
Affinity DataIC50:  720nMAssay Description:Inhibition of iNOS in intact human DLD1 cells assessed as nitric oxide productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340004((R)-2-(3-amino-1-(isoxazol-5-yl)propoxy)-6-(triflu...)
Affinity DataIC50: >1.40E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed