BDBM50341408 CHEMBL4166594::US11534443, Example 29
SMILES CNc1nc(C)c2cc(cc(OC3CCOCC3)c2n1)-c1cnc(OC)c(NS(=O)(=O)c2ccc(F)cc2F)c1
InChI Key InChIKey=IEDGFXCUFJCEAP-UHFFFAOYSA-N
Data 14 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50341408
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 0.350nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1-Hydroxymidazolam formation using midazolam as substrate after 10 to 20 mins...More data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as reduction in 4-Hydroxymephenytoinn formation using mephenytoin as substrate after 10 to 2...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin) using FAM-labeled peptide as substrate by mobility shift assayMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as reduction in acetaminophen formation using phenacetin as substrate after 10 to 20 mins in ...More data for this Ligand-Target Pair
TargetCytochrome P450 2E1(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as reduction in 6-Hydroxychlorzoxazone formation using chlorzoxazone as substrate after 10 to...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Homo sapiens (Human))
Institute of Materia Medica, Chinese Academy of Medical Sciences
US Patent
Institute of Materia Medica, Chinese Academy of Medical Sciences
US Patent
Affinity DataIC50: 1.10nMAssay Description:The Kinase-Glo™ Kinase Assay Kit was purchased from Promega. All assays were performed at room temperature using white OptiPlate™-384 well plate. The...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cell membranes by patch clamp methodMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as reduction in dextrophan formation using detromethorphann as substrate after 10 to 20 mins ...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as reduction in 4-Hydroxydiclofenac formation using diclofenac as substrate after 10 to 20 mi...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of mTOR (unknown origin) using ULight-4E-BP1 peptide as substrate after 30 mins by Lance Ultra assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate by Kinase-Glo assayMore data for this Ligand-Target Pair