BDBM50343561 8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-1-(2-(tetrahydro-2H-pyran-4-yloxy)ethyl)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774338

SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCOC5CCOCC5)c4-c3n2)C(N)=O)c1

InChI Key InChIKey=UPPBHPLFAHWJFR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343561   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343561(8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)...)
Affinity DataIC50:  43nMAssay Description:Inhibition of PLK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343561(8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of PLK3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343561(8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed