BDBM50344902 1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imidazo[2,1-b]purine-7,1'-inden]-4(1H)-one::CHEMBL1778033

SMILES CCN1C2=NC3(CCc4ccccc34)CN2c2c(nc(Cc3ccccc3)n2Cc2ccccc2)C1=O

InChI Key InChIKey=YAQRTUXYVQSHDL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50344902   

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344902(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Affinity DataIC50:  140nMAssay Description:Inhibition of PDE11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344902(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344902(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human ERG by voltage-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344902(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Affinity DataIC50:  233nMAssay Description:Antagonist activity at rat P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344902(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Affinity DataIC50:  248nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed