BDBM50349090 CHEMBL1807301

SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(=O)N3CCC[C@H]3CN3CCCC3)nc-21

InChI Key InChIKey=LTKUHPWNVCRTSA-NDEPHWFRSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50349090   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349090(CHEMBL1807301)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK1 assessed as [33P]-gamma-ATP incorporation into substrate by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349090(CHEMBL1807301)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]-gamma-ATP incorporation into substrate by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349090(CHEMBL1807301)
Affinity DataIC50:  491nMAssay Description:Inhibition of Aur-A assessed as [33P]-gamma-ATP incorporation into substrate by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349090(CHEMBL1807301)
Affinity DataIC50:  72nMAssay Description:Inhibition of MPS1 assessed as [33P]-gamma-ATP incorporation into substrate P38-betatide by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed