BDBM50351935 CHEMBL1821728

SMILES C[C@H](Cc1cc2cc(ccc2nc1N)-c1ccccc1C)C(=O)N[C@@H]1CCOC(C)(C)C1

InChI Key InChIKey=QMSHBBGXSXAGOO-XMSQKQJNSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50351935   

TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50351935(CHEMBL1821728)
Affinity DataIC50:  18nMAssay Description:Inhibition of BACE1 in human HEK293 cells expressing APP with Swedish mutation assessed as amyloidbeta 40 level by sandwich ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50351935(CHEMBL1821728)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant BACE1 after 60 mins by FRET assayMore data for this Ligand-Target Pair