BDBM50352939 CHEMBL1824913::WO2022112139, Example 9

SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1

InChI Key InChIKey=WBYRHHSGTGEDGI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50352939   

TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50352939(CHEMBL1824913 | WO2022112139, Example 9)
Affinity DataIC50:  89nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExternal core antigen(HBVgbn)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM50352939(CHEMBL1824913 | WO2022112139, Example 9)
Affinity DataIC50:  1.69E+3nMAssay Description: Detailed procedures regarding primary human hepatocyte (PHH) HBV natural infection assay are described as below. One tube of frozen PHH (10 million ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLarge envelope protein(Hepatitis B virus)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM50352939(CHEMBL1824913 | WO2022112139, Example 9)
Affinity DataIC50:  8.23E+3nMAssay Description: Detailed procedures regarding primary human hepatocyte (PHH) HBV natural infection assay are described as below. One tube of frozen PHH (10 million ...More data for this Ligand-Target Pair
In DepthDetails PubMed