BDBM50355418 CHEMBL1835151

SMILES NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c2c3ccc(cc3[nH]c12)-c1cnc(nc1)N1CCOCC1

InChI Key InChIKey=DALGRIWHYIBOST-OAQYLSRUSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50355418   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50355418(CHEMBL1835151)
Affinity DataIC50:  430nMAssay Description:Inhibition of JAK3 using biotin-EQEDEPEGDYFEWLE- NH2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50355418(CHEMBL1835151)
Affinity DataIC50:  530nMAssay Description:Inhibition of JAK2-mediated STAT5 phosphorylation in human HEL 92.1.7 irf1-bla cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50355418(CHEMBL1835151)
Affinity DataIC50:  8nMAssay Description:Inhibition of JAK2 using biotin-EQEDEPEGDYFEWLE- NH2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed