BDBM50358043 CHEMBL1794051::GW-5074
SMILES OC1Nc2ccc(I)cc2C1=Cc1cc(Br)c(O)c(Br)c1
InChI Key InChIKey=UFKSWYKDQZBJTH-UHFFFAOYSA-N
Data 19 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50358043
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanyang University
Curated by ChEMBL
Hanyang University
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human CRAF using [gamma-33P]ATP after 40 mins by scintillation countingMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanyang University
Curated by ChEMBL
Hanyang University
Curated by ChEMBL
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanyang University
Curated by ChEMBL
Hanyang University
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibitory concentration against raf kinase.More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor)More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanyang University
Curated by ChEMBL
Hanyang University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of c-Raf1 kinaseMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human Sirt5 deacetylation activity using SKEYFS-acetylLys-QK as substrate measured for 15 mins by MS analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataIC50: 9.78E+4nMAssay Description:Inhibition of human Sirt5 deacetylation activity using FKRGVL-acetylLys-EYGVKV as substrate measured for 15 mins by MS analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of human Sirt5 desuccinylation activity using SKEYFS-succinylLys-QK as substrate measured for 15 mins by MS analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of B-Raf in the presence of 100uM ATPMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanyang University
Curated by ChEMBL
Hanyang University
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of c-Raf in the presence of 100uM ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of PIM1 in the presence of 20uM ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of PIM2 in the presence of 5uM ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of PIM3 in the presence of 20uM ATPMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanyang University
Curated by ChEMBL
Hanyang University
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of Raf1 kinaseMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of human recombinant N-terminally 6X-His-tagged SIRT2 after 4 hrs in presence of NAD+ by fluorescent deacetyalse assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human recombinant N-terminally 6X-His-tagged SIRT3 after 4 hrs in presence of NAD+ by fluorescent deacetyalse assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-Universit£T M£Nchen
Curated by ChEMBL
Affinity DataIC50: 4.16E+4nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged SIRT1 after 4 hrs in presence of NAD+ by fluorescent deacetyalse assayMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanyang University
Curated by ChEMBL
Hanyang University
Curated by ChEMBL
Affinity DataIC50: 2.87nMAssay Description:Inhibition of C-Raf assessed as [33P]gamma-ATP incorporation into substrate after 40 mins by scintillation countingMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanyang University
Curated by ChEMBL
Hanyang University
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of cRaf1 kinase in cascade assayMore data for this Ligand-Target Pair