BDBM50365216 CHEMBL1956070::ROCHE screening, 76

SMILES CN1CCN(CC1)c1ccc(Nc2nc(N)c(s2)C(=O)c2ccc3OCCOc3c2)cc1

InChI Key InChIKey=YGEYFDLYGXSZCP-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50365216   

TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM50365216(CHEMBL1956070 | ROCHE screening, 76)
Affinity DataIC50:  460nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50365216(CHEMBL1956070 | ROCHE screening, 76)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human GST-tagged CDK4-cyclin D1 using his-tagged Rb as substrate after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50365216(CHEMBL1956070 | ROCHE screening, 76)
Affinity DataIC50:  7.10E+7nMAssay Description:Inhibition of insulin receptor using fluorescent substrate by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50365216(CHEMBL1956070 | ROCHE screening, 76)
Affinity DataIC50:  3.04E+6nMAssay Description:Inhibition of human CDK1-GST-tagged cyclin B using his-tagged Rb as substrate after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50365216(CHEMBL1956070 | ROCHE screening, 76)
Affinity DataIC50: >2.00E+7nMAssay Description:Inhibition of c-Met using fluorescent substrate by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50365216(CHEMBL1956070 | ROCHE screening, 76)
Affinity DataIC50:  3.21E+6nMAssay Description:Inhibition of Src using fluorescent substrate by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50365216(CHEMBL1956070 | ROCHE screening, 76)
Affinity DataIC50:  2.20E+7nMAssay Description:Inhibition of IGF1R using fluorescent substrate by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50365216(CHEMBL1956070 | ROCHE screening, 76)
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of Lck using fluorescent substrate by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50365216(CHEMBL1956070 | ROCHE screening, 76)
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of ERK1 using fluorescent substrate by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50365216(CHEMBL1956070 | ROCHE screening, 76)
Affinity DataIC50:  2.36E+6nMAssay Description:Inhibition of human CDK2-GST-tagged cyclin E using his-tagged Rb as substrate after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed