BDBM50370181 CHEMBL4159382::US11117865, Compound ZL0454
SMILES Cc1cc(\N=N\c2ccc(cc2)S(=O)(=O)NC2CCCC2)c(N)cc1O
InChI Key InChIKey=IRKMSULWLDLTIK-QZQOTICOSA-N
Data 22 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 22 hits for monomerid = 50370181
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 810nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG54 RNA expression preincubated for 24 hrs followed ...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 32nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced grobeta RNA expression preincubated for 24 hrs followe...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 2(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetBromodomain testis-specific protein(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 3.29E+3nMAssay Description:Inhibition of BRDT BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibition of BRD3 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 860nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG56 RNA expression preincubated for 24 hrs followed ...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 730nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced IL-8 RNA expression preincubated for 24 hrs followed b...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of BRD3 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetBromodomain testis-specific protein(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 3.08E+3nMAssay Description:Inhibition of BRDT BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CBP (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 2 [91-163](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 772nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 2 [364-436](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 1.84E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 3 [51-123](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 2.49E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 3 [326-398](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 2.24E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
TargetBromodomain testis-specific protein [22-138](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 3.29E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
TargetBromodomain testis-specific protein [287-359](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 3.08E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 49nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 2(Homo sapiens (Human))
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 772nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair