BDBM50375595 CHEMBL185878::Taurochenodeoxycholate

SMILES C[C@H](CCC(=O)NCCS(O)(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI Key InChIKey=BHTRKEVKTKCXOH-BJLOMENOSA-N

Data  3 KI  1 IC50  4 EC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50375595   

TargetSolute carrier organic anion transporter family member(Danio rerio (Zebrafish))
Rudjer Boskovic Institute

LigandPNGBDBM50375595(CHEMBL185878 | Taurochenodeoxycholate)
Affinity DataKi:  3.40E+3nMAssay Description:In the inhibition experiments, the cells were preincubated for 20 s with test compounds, followed by a 5-min incubation with [3H]E3S (5 nM) or 30-min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Homo sapiens (Human))
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50375595(CHEMBL185878 | Taurochenodeoxycholate)
Affinity DataKi:  6.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
King'S College Hospital

Curated by ChEMBL
LigandPNGBDBM50375595(CHEMBL185878 | Taurochenodeoxycholate)
Affinity DataKi:  2.80E+4nMAssay Description:TP_TRANSPORTER: competitive inhibition of Taurocholate uptake in membrane vesicles prepared from High Five cells infected with the ABCB11 baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Heinrich Heine University

Curated by ChEMBL
LigandPNGBDBM50375595(CHEMBL185878 | Taurochenodeoxycholate)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Heinrich Heine University

Curated by ChEMBL
LigandPNGBDBM50375595(CHEMBL185878 | Taurochenodeoxycholate)
Affinity DataEC50:  2.96E+4nMAssay Description:Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Heinrich Heine University

Curated by ChEMBL
LigandPNGBDBM50375595(CHEMBL185878 | Taurochenodeoxycholate)
Affinity DataEC50:  1.92E+3nMAssay Description:Agonist activity at human TGR5 expressed in CHO cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50375595(CHEMBL185878 | Taurochenodeoxycholate)
Affinity DataEC50:  3.00E+3nMAssay Description:Binding affinity for Farnesoid X Receptor (FXR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
The Netherlands Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50375595(CHEMBL185878 | Taurochenodeoxycholate)
Affinity DataIC50:  5.50E+4nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicles from MRP4-expressing HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed