BDBM50379362 CHEMBL2011939

SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)c3cccs3)c2[nH]1

InChI Key InChIKey=NSNZIHNPWOUVQN-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50379362   

TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50379362(CHEMBL2011939)
Affinity DataEC50:  26nMAssay Description:Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50379362(CHEMBL2011939)
Affinity DataIC50:  541nMAssay Description:Inhibition of Ikkepsilon using 5FAM-AKELDQGSLCTpSFVGTLQ-NH2 as substrate by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50379362(CHEMBL2011939)
Affinity DataIC50:  46nMAssay Description:Inhibition of recombinant TBK1 using 5FAM-AhxKRRAL(ps)VASLPGL as substrate by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed