BDBM50380881 CHEMBL2018953
SMILES Clc1ccc(CNc2nc(nc3ncccc23)N2CCN(CC2)C(=O)[C@H]2CCCCN2)c(Cl)c1
InChI Key InChIKey=GDQQUDANFRCFMF-HXUWFJFHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50380881
Affinity DataKi: 0.794nMAssay Description:Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPAMore data for this Ligand-Target Pair
Affinity DataKd: 50.1nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayMore data for this Ligand-Target Pair