BDBM50381996 CHEMBL2022373

SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)Nc2cccc(F)c2F)c1

InChI Key InChIKey=OPFNFKIYQOOQMS-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50381996   

TargetAurora kinase B(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataEC50:  58nMAssay Description:Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50:  20nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50:  122nMAssay Description:Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50:  481nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed