BDBM50382012 CHEMBL2023301

SMILES COc1cccc(CNC(=O)Cn2cc(cn2)-c2cnc3c(Nc4cc(CN5CCCC(C)C5)ns4)nc(C)cn23)c1

InChI Key InChIKey=GANVFRXETVPEAB-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50382012   

TargetAurora kinase B(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50382012(CHEMBL2023301)
Affinity DataEC50:  442nMAssay Description:Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50382012(CHEMBL2023301)
Affinity DataIC50:  57nMAssay Description:Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50382012(CHEMBL2023301)
Affinity DataIC50:  41nMAssay Description:Inhibition of aurora B kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed