BDBM50384321 CHEMBL2030856::US9346795, 245

SMILES CCCCc1c(c(CO)nn1-c1ccc(CCO)cc1)-c1ccc(cc1C(=O)N1CCc2ccccc2C1)C(=O)NS(=O)(=O)c1ccc2ccccc2c1

InChI Key InChIKey=JETFGVBOZMHEJM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50384321   

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50384321(CHEMBL2030856 | US9346795, 245)
Affinity DataIC50:  20nMT: 2°CAssay Description:The assays were performed in black flat-bottom 384-well plates. The final assay volume was 50 μl prepared from additions of Gst-Bcl-2 (Bcl-2: GE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50384321(CHEMBL2030856 | US9346795, 245)
Affinity DataIC50:  6nMAssay Description:Inhibition of biotin-labelled Bcl-xL using [FAM]-IWIAQELRRIGDEFNAYY-NH2 as substrate after 60 mins by FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50384321(CHEMBL2030856 | US9346795, 245)
Affinity DataIC50:  20nMAssay Description:Inhibition of GST-tagged Bcl2 using [FAM]-IWIAQELRRIGDEFNAYY-NH2 as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50384321(CHEMBL2030856 | US9346795, 245)
Affinity DataIC50:  6.14nMT: 2°CAssay Description:The assays were performed in black flat-bottom 384-well plates. The final assay volume was 55 μl prepared from additions of Biotin-Bcl-xL (Bcl-x...More data for this Ligand-Target Pair
In DepthDetails US Patent