BDBM50387922 CHEMBL2058685::US9283222, 476

SMILES COCCC(=O)Nc1cc(Cc2n[nH]c(=O)c3CCCNc23)ccc1F

InChI Key InChIKey=HCXMNLCCKOKFQJ-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50387922   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM50387922(CHEMBL2058685 | US9283222, 476)
Affinity DataKi:  12nMpH: 8.0Assay Description:PARP1 assay was conducted in PARP assay buffer containing 50 mM Tris pH 8.0, 1 mM DTT, 4 mM MgCl2. PARP reactions contained 1.5 uM [3H]-NAD+ (1.6 uCi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM50387922(CHEMBL2058685 | US9283222, 476)
Affinity DataKi:  12nMAssay Description:Inhibition of PARP1 using [3H]NAD+ after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM50387922(CHEMBL2058685 | US9283222, 476)
Affinity DataEC50:  134nMAssay Description:Inhibition of PARP1 in H202-stimulated human C41 cells incubated for 30 mins prior to H2O2-treatment measured after 10 mins by FITC-based immunostain...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed