BDBM50392982 CHEMBL2152382

SMILES COC(=O)c1c(Cc2ccc(cc2)C(=O)NCCO)c(=O)c2ccc(Cl)cc2n1-c1ccccc1

InChI Key InChIKey=STNCBMGTCZRJPA-UHFFFAOYSA-N

Data  3 IC50  18 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50392982   

TargetSerine/threonine-protein kinase 17A(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged STK17A by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataEC50:  1.01E+4nMAssay Description:Inhibition of JNK1-mediated c-jun phosphorylation in TNF-alpha stimulated human HK-2 cells after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd:  62nMAssay Description:Binding affinity to T7-phage-tagged JNK1 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataIC50:  62nMAssay Description:Inhibition of human JNK1 alpha1 using GST-tagged ATF2 as substrate and [gamma33P]ATP incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged RPS6KA1 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged CDK7 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase RIO2(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged RIOK2 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase DCLK3(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged DCAMKL3 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged MAPK7 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase family member 4(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged SgK085 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged MAP2K4 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 2(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged DAPK2 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 15(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged MAPK15 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 3(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged DAPK3 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged IRAK1 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged P38delta by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 1(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged DAPK1 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged P38gamma by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to T7-phage-tagged IKKbeta by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataKd:  170nMAssay Description:Binding affinity to T7-phage-tagged JNK2 by PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataIC50:  44nMAssay Description:Inhibition of JNK1 after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataIC50:  170nMAssay Description:Inhibition of human JNK2 alpha2 using GST-tagged ATF2 as substrate and [gamma33P]ATP incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed