BDBM50393720 CHEMBL2159122::CHEMBL3216329

SMILES Cl.Cl.COc1ccc(CN(C(C)c2nc(c[nH]2)-c2ccccc2)C(=O)C(N)Cc2c(C)cc(cc2C)C(N)=O)cc1C(O)=O

InChI Key InChIKey=QFNHIDANIVGXPE-FNZWTVRRSA-N

Data  4 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50393720   

TargetMu-type opioid receptor(Rattus norvegicus (rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50393720(CHEMBL2159122 | CHEMBL3216329)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to rat mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50393720(CHEMBL2159122 | CHEMBL3216329)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to rat delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50393720(CHEMBL2159122 | CHEMBL3216329)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50393720(CHEMBL2159122 | CHEMBL3216329)
Affinity DataKi:  55nMAssay Description:Binding affinity to guinea pig kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50393720(CHEMBL2159122 | CHEMBL3216329)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at delta opioid receptor expressed in CHO-hg cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50393720(CHEMBL2159122 | CHEMBL3216329)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at kappa opioid receptor guinea pig colon tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50393720(CHEMBL2159122 | CHEMBL3216329)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-astemizole from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50393720(CHEMBL2159122 | CHEMBL3216329)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50393720(CHEMBL2159122 | CHEMBL3216329)
Affinity DataEC50:  1nMAssay Description:Binding affinity to human mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed