BDBM50400094 CHEMBL427092

SMILES COC(=O)c1ccc(O)c(NC(=O)COc2ccc(cc2)C23CC4CC(CC(C4)C2)C3)c1

InChI Key InChIKey=BJRPPNOJYFZSLY-UHFFFAOYSA-N

Data  1 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50400094   

TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataKi:  1.90E+3nMAssay Description:Competitive inhibition of MDH2 (unknown origin) using varying NADH level by oxaloacetate-dependent NADH oxidation based Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of MDH2 (unknown origin) pre-incubated for 1 hr followed by malate and NAD+ additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of MDH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of MDH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korea Research Institute Of Bioscience And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of hypoxia induced HIF1 transcriptional activity in human Hep3B cells by cell-based HRE reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataIC50:  3.08E+3nMAssay Description:Inhibition of HIF1alpha transcriptional activity in hypoxia-induced human HCCLM3 cells co-transfected with luciferase reporter plasmid containing fiv...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of HIF-1alpha in human HCT116 cells incubated for 12 hrs under hypoxic conditions by Western blotting and HRE-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataIC50:  2.44E+3nMAssay Description:Inhibition of HIF1alpha in human HCT116 cells under hypoxic condition after 16 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed