BDBM50400517 CHEMBL2204935
SMILES Cc1nc(no1)[C@@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)cc1)c1cnn(C)c1
InChI Key InChIKey=NTIFDLOQPKMIJK-AJTFRIOCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 50400517
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataKi: 1.70E+3nMAssay Description:Displacement of radiolabeled MK-499 from human ERG channelMore data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:Displacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.950nMAssay Description:Inhibition of human SSTR3 transfected in CHO cells assessed as inhibition of SRIF-induced reduction of cAMP accumulation after 45 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:Inhibition of mouse SSTR3 transfected in CHO cells assessed as inhibition of SRIF-induced reduction of cAMP accumulation after 45 minsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human ERG by functional patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of human ERG by MK-499 displacement binding analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity against human recombinant SSTR3 expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation in presence o...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human ERG by Patchexpress patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Displacement of [125I]SS-14 from human recombinant SSTR3 expressed in CHO cell membranes incubated for 60 to 90 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Binding affinity to human ERG by patchXpress functional assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
Affinity DataEC50: 0.950nMAssay Description:Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:Binding affinity to human somatostatin receptor type 3More data for this Ligand-Target Pair
Affinity DataIC50: 533nMAssay Description:Displacement of [125I]SS-28 from human SSTR-5 transfected in CHO cells after 90 to 120 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 384nMAssay Description:Displacement of [125I]SS-28 from human SSTR-4 transfected in CHO cells after 60 to 90 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.03E+3nMAssay Description:Displacement of [125I]SS-14 from human SSTR-2 transfected in CHO cells after 60 to 90 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.36E+3nMAssay Description:Displacement of [125I]SS-28 from human SSTR-1 transfected in CHO cells after 60 to 90 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.360nMAssay Description:Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity at human SST3 expressed in CHO-K1 cells assessed as inhibition of SRIF-14-induced foreskin-stimulated cAMP accumulation after 45 ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:Antagonist activity at mouse SST3 expressed in CHO-K1 cells assessed as inhibition of SRIF-14-induced foreskin-stimulated cAMP accumulation after 45 ...More data for this Ligand-Target Pair