BDBM50413752 CHEMBL2012519::L-783277

SMILES COc1cc(O)c2c(CCCC(=O)C(=O)C(O)CCC[C@H](C)OC2=O)c1

InChI Key InChIKey=CZVAYVPOBIDGLC-ZSOXZCCMSA-N

Data  47 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50413752   

TargetEphrin type-B receptor 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EPHB4 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  640nMAssay Description:Inhibition of MK5 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RET by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of TYK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  950nMAssay Description:Inhibition of ERK2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora A kinase by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Axl by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BTK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ZAP70 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EPHA4 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HGFR by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGF1R by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK3 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKN1 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKN2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ROCK2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  763nMAssay Description:Inhibition of ALK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of INSR by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  15nMAssay Description:Inhibition of MEK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  2nMAssay Description:Inhibition of VEGFR2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of p38alpha by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK2A by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HER2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKAalpha by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  303nMAssay Description:Inhibition of cKIT by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GSK3-beta by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR3 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  57nMAssay Description:Inhibition of VEGFR2 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  36nMAssay Description:Inhibition of recombinant FLT3 ITD mutant (unknown origin) by RBC kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  62nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant FLT3 D835Y mutant (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of LCK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed