BDBM50413999 CGP77675::CHEMBL475584

SMILES COc1cccc(c1)-c1cn(-c2ccc(CCN3CCC(O)CC3)cc2)c2ncnc(N)c12

InChI Key InChIKey=WUPXZZWTHIZICK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50413999   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ankara University

LigandPNGBDBM50413999(CGP77675 | CHEMBL475584)
Affinity DataIC50:  0.400nMT: 2°CAssay Description:Kinase activity (Src-family kinases, Hck, Lyn, Fyn, and c-Src) and the effect of the molecules were determined by ProFluor Src-Family Kinase Assay Ki...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ankara University

LigandPNGBDBM50413999(CGP77675 | CHEMBL475584)
Affinity DataIC50:  19.9nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50413999(CGP77675 | CHEMBL475584)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant His-tagged EGFR expressed in baculovirus using poly-Gluo-Tyr as a substrate measured after 24 hrs by western blot ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ankara University

LigandPNGBDBM50413999(CGP77675 | CHEMBL475584)
Affinity DataIC50:  20nMAssay Description:Inhibition of c-Src kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ankara University

LigandPNGBDBM50413999(CGP77675 | CHEMBL475584)
Affinity DataIC50:  20nMAssay Description:Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Indo-Soviet Friendship College Of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50413999(CGP77675 | CHEMBL475584)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Lyn (unknown origin) using Src-family kinase bisamide rhodamine 110 peptide substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed