BDBM50428112 CHEMBL2331665::US8791131, 162

SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)C(C)(C)O)c3c2n1

InChI Key InChIKey=HLUSJQCZTNOZHI-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50428112   

LigandPNGBDBM50428112(CHEMBL2331665 | US8791131, 162)
Affinity DataKi:  3.89nM ΔG°:  -11.5kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50428112(CHEMBL2331665 | US8791131, 162)
Affinity DataKi:  3.90nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50428112(CHEMBL2331665 | US8791131, 162)
Affinity DataKi:  18.5nM ΔG°:  -10.5kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50428112(CHEMBL2331665 | US8791131, 162)
Affinity DataKi:  19nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed